Evaluation and Comparison of Dermo-Cosmetic Activities of Three Oak Species by Targeting Antioxidant Metabolites and Skin Enzyme Inhibitors

The two main species, sessile oak (Quercus petraea Liebl.) and pedunculate robur L.), predominant in French forests, are mainly used for aging wines spirits; however, the potential of wood extract as a source natural antioxidants, due to its high polyphenol content, could be more widely exploited. This study focuses on three that well-known, namely, oak, third has seldom been described valorized, pubescent pubescens). Water extracts these species were fractionated by semi-preparative HPLC. antioxidant activities crude fractions measured colorimetric enzymatic tests. anti-elastase anti-collagenase their also evaluated. In parallel, samples analyzed UHPLC-HRMS correlate activity with molecular composition using networks. results obtained total compared determine if depended species. within same highlight which fraction and, therefore, family was involved extract. various tests showed good very activity. already proven literature this is correlated richness polyphenols. shows each contributes Oak can neutralize ROS produced during oxidative stress prevent degradation collagen elastase skin aging. Its complementary properties make valuable ingredient act against